comparison of genomic evaluation methods in complex traits with different genetic architecture
نویسندگان
چکیده
the objective of this study was to compare six statistical methods for prediction of genomic breedingvalues for traits with different genetic architecture in term of gene effects distributions and number ofquantitative traits loci (qtls). a genome consisted of 500 bi-allelic single nucleotide polymorphism(snp) markers distributed over a chromosomes with 100 cm length was simulated. three different geneeffects distributions (uniform, normal and gamma) were considered. number of qtls varied from 50 to200. finally, nine quantitative traits with different genetic architecture were generated. the performanceof six statistical methods of genomic prediction that differ with respect to assumptions regardingdistribution of marker effects, including i) genomic best linear unbiased prediction (gblup), ii) ridgeregression best linear unbiased prediction (rrblup), iii) bayes a, iv) bayes b, v) bayes c, and vi)bayesian least absolute shrinkage and selection operator (bayes l) are presented. the accuracy ofprediction declined significantly over generations (p< 0.05) but bayesian methods outperformed gblupand rrblup in persistence of accuracy of genomic estimated breeding values over generations.bayesian methods were superior to gblup and rrblup when the gene effects distribution generatedfrom gamma distribution. the highest accuracy of genomic breeding values was observed when the geneeffects come from normal distribution. in all statistical evaluation methods with increasing the number ofqtls towards 200, the accuracy of predicted genomic values has been decreased. in general, bayesianand gblup methods performed better in prediction than rrblup method. these results gave someevidences that when the genetic architecture of quantitative traits deviated from infinitesimal modelassumptions, bayesian methods usually perform better than gblup and rr-blup.
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عنوان ژورنال:
تولیدات دامیجلد ۱۵، شماره ۱، صفحات ۶۵-۷۷
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